The Right Stress Can Lengthen Your Life

If there’s one thing we think we know, it’s that stress is bad for us. However, what if that just isn’t true?

The startling truth gleaned from recent studies is that some forms of stress are very good for us. It appears that Nietzsche was right when he said, “That which does not kill us, makes us stronger.” Our biggest problem is the lack of stress. However, the type and quality of stress we are under defines whether it will help or hurt us.

Human beings evolved over millennia in a world that bears little resemblance to the one we inhabit today. Food shortages and changes in temperature were common as our species evolved, and daily physical exercise was a given. Today, most of us have an abundance of food that we eat in climate-controlled environments. We can limit our movement from bed to the refrigerator, and onto the lounge chair.

This modern utopia created in the name of progress has spawned an explosion of health problems. Obesity, diabetes, heart disease and hypertension are the rewards of our cushy lifestyle. We have managed to remove the stressors that ensured optimal health.

Stressed Cells are Healthier

A team of researchers at the Salk Institute have found a way to remodel mitochondria via short-term stress to generate fewer toxic byproducts. These byproducts cause the mitochondria to deteriorate over time, so lessening their number should enable scientists to find new approaches to fight aging on a cellular level.

"The novelty of this study is that we've generated a model in which we can turn off antioxidant production in mitochondria but in a reversible way," says Salk Professor Gerald Shadel, the senior author of the paper. "So we were able to induce this stress for specific time windows and see how cells responded.”

Mitochondria power cells by converting food into chemical energy. In the process, a chemical known as superoxide is created. Superoxide is critical to cellular function, but too much of it can be toxic. So mitochondria also produce an enzyme known as superoxide dismutase (SOD) to convert the superoxide to a less toxic substance.

A group of mice whose SOD enzyme had been turned off briefly to trigger stress in mitochondria looked the same as genetically identical mice at four weeks of age. However, researchers discovered a surprising difference. The stressed mice had more mitochondria with less superoxide buildup and higher levels of antioxidants than the control mice. In other words, the stressed mice were healthier, at least from a cellular point of view.

The team found that the stressed mice had developed unexpected molecular pathways that reprogrammed the mitochondria to produce fewer toxic molecules, while at the same time stimulating the cells’ antioxidant capacity.

Shadel, who holds the Audrey Geisel Chair in Biomedical Science, adds, "We are excited to test if the unique mitohormesis signaling pathways we will elucidate in this new mouse model can be targeted to prevent common age-related disease like cancer, Alzheimer's and heart disease.”

Good Stressors

On a more practical level, several stressors have been identified that can help you live a better life today. These are specific and short in duration rather than the chronic, all-encompassing stressors associated with negative outcomes.

The best way to extend an animal’s lifespan (including that of humans) is by calorie restriction. (See sidebar). Reduce food intake, and not only does lifespan lengthen, but it triggers a cellular response that increases resistance to chronic diseases and inhibits the aging process. One way this works is by reducing inflammation. Science has found that inflammation accompanies the early stages of many chronic conditions.

The inflammation induced by exercise would seem to indicate that it’s better to be sedentary. But in spite of this short-term effect, the more enduring result of exercise is a strong anti-inflammatory effect. Interestingly, when you take the antioxidants vitamin E and C before a workout, the beneficial effects go away. The body needs the mild irritation caused by exercise to derive therapeutic benefits.

Like people, plants also have had to adapt to the environment. Unlike humans, a plant can’t move to get away from stress. Dangers are many, including UV radiation from the sun, hungry bugs and herbivores, and fluctuations in temperature, rainfall and soil nutrients. Plants have had much longer than humans to adapt differing responses to these stressors we have in common.

It’s no coincidence that about half of all drugs approved during the last 30 years are sourced directly or indirectly from plants. Morphine (1826) and aspirin (1899) are a pair of plant-based remedies still in use today. Consuming plant foods can help us resist disease, but our modern diets contain far fewer plants than those of our hunter-gatherer ancestors. Furthermore, instead of wild food, we eat an abundance of factory-farmed produce with the resistance bred out or genetically modified.

Add Good Stress

Make sure your doctor approves any changes before you switch up your routine. There are several ways to kick-start your mitochondria. Try one or several to find out what works for you.

•  Decrease the number of calories you consume. Studies show that stretching out the time you don’t eat can be helpful. Instead of breakfast at 7 a.m. and a late-night snack, you could try eating dinner at 6 p.m. and then fasting until breakfast.
•  Put more vegetables and fruit into your diet. Organic produce is preferred for low pesticide levels and look for non-GMO produce.
•  Do something physical every day. Hunter-gatherers traveled long periods at a slow pace, interspersed with short intervals of intense exertion. Mimic this stressor with exercise, such as a long walk with sprint intervals. Also, take your vitamins any time except before you exercise.
•  Turn down the heat, or run some cold water at the beginning or end of your shower. Spend time outdoors no matter the season. 

Sources:

https://www.ncbi.nlm.nih.gov/pubmed/15839378
https://www.huffpost.com/entry/healthy-lifestyle-tips_b_2883770
https://www.sciencedaily.com/releases/2018/08/180816143121.htm
https://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.43.100901.140223
https://www.ncbi.nlm.nih.gov/pubmed/17964227
http://www.berkeleywellness.com/#
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560124/
https://www.sciencedaily.com/releases/2018/03/180322141008.htm